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Cardiology

HEART Score (Chest Pain Stratification)

Risk-stratify chest pain in the Emergency Department to predict 6-week Major Adverse Cardiac Events (MACE). The standard tool for safe discharge decisions vs admission.

Select an option for all 5 criteria to see the HEART score.

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Also Known As

HEART scoreHEART pathwaychest pain ED triageMACE 6 weekACS rule outlow risk chest pain dischargeNSTEMI risk stratificationtroponin chest painhigh sensitivity troponinIndia emergency medicineCSI ACS guidelineschest pain unitobservation unit chest painAHA chest pain 2021ED disposition chest pain

What is the HEART score?

The HEART score (History, ECG, Age, Risk factors, Troponin) is the most widely validated tool for risk-stratifying chest pain in the Emergency Department. It predicts 6-week Major Adverse Cardiac Events (MACE) — death, MI, or urgent revascularisation — and identifies patients who can be safely discharged.

Range: 0–10. Each of the 5 components is scored 0, 1 or 2.

MACE Risk by Score (validation cohorts)

  • 0–3 (Low): 1.7% MACE → discharge with outpatient follow-up
  • 4–6 (Moderate): 16.6% MACE → admit for observation + further workup
  • 7–10 (High): 50.1% MACE → early invasive strategy (angiography ≤ 24–72h)

HEART Pathway vs HEART Score

The HEART Pathway adds a 0- and 3-hour troponin to the HEART score. Patients with HEART ≤ 3 AND both troponins negative are discharged. The HEART Pathway has been shown in RCTs to reduce admission rates by ~20% with no missed MACE.

Risk Factor Definition (the "R")

  • Hypertension
  • Hypercholesterolaemia
  • Diabetes mellitus
  • Current/recent smoker
  • Family history of CAD (first-degree relative, M < 55, F < 65)
  • Obesity (BMI > 30; consider lower threshold for South Asian patients)
  • Known atherosclerotic disease (prior MI, PCI, CABG, stroke, PAD) → automatic 2 points

Frequently Asked Questions

Can I discharge a HEART score 3 patient without troponin?

No. The score requires at least one troponin. If using conventional troponin, the HEART Pathway recommends a second troponin at 3h before discharge. With high-sensitivity troponin and a negative single sample, the 0/1h or 0/3h hsTn algorithms can be combined with HEART.

How does HEART compare to TIMI and GRACE scores?

HEART outperforms TIMI and GRACE for ED chest pain risk stratification (higher sensitivity for low-risk identification). TIMI is better for confirmed UA/NSTEMI to guide invasive vs conservative; GRACE for in-hospital mortality after confirmed ACS.

Is HEART score validated in South Asian / Indian patients?

Yes — multiple cohort studies from India and the UK South Asian population confirm validity. Note: Indians develop CAD ~10 years earlier, so the &quot;Age &lt; 45&quot; cutoff misses some at-risk young Indian patients — use clinical judgment alongside the score.

What counts as &quot;significant ST depression&quot; on the ECG component?

New, horizontal or downsloping ST depression ≥ 0.5 mm in 2 contiguous leads. ST elevation = STEMI, do not use HEART. LBBB, paced rhythms, and LVH with strain confound the ECG component — score as &quot;non-specific repolarisation&quot; (1 point).

Should I use HEART for cocaine-related chest pain?

It has not been validated in this population. Cocaine/sympathomimetic chest pain has a different mechanism (coronary spasm, demand ischaemia) and patients are typically younger with low traditional risk factors but still at MI risk. Use clinical judgment + troponin + observation.

Clinical Disclaimer: HEART score is validated for adult ED patients with chest pain suspicious for ACS. Do not use for STEMI (already a high-risk diagnosis), trauma, or non-cardiac obvious causes. Always combine with clinical gestalt — score is a guide, not a substitute for judgment. Always verify against your local prescribing reference and apply clinical judgment.

References

Chest pain workflow, end to end

EasyClinic captures HEART score, ECG findings, serial troponins, and prior risk factors on a single screen — and auto-flags low-risk patients eligible for discharge per HEART pathway.

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