EasyClinic Drug Reference

Indian clinical drug database

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Antidiabetic · Sulfonylurea (second-generation)

Gliclazide (Gliclazide)

Also sold as: Diamicron, Glyclazide, Gliclazid

Pregnancy

Cat C

Lactation

Unknown

Schedule

Forms

Tablet 80mg +2

Indications

Type 2 diabetes (combination or monotherapy)
When diet and exercise insufficient

Adult Dosing

Initiation

80 mg once or twice daily

Adjust dose based on glucose response

Maintenance

80-320 mg/day divided

Long-term

Modified-release

30 mg once daily with breakfast

Long-term, better glycemic control

Extended-release

60 mg once daily

Long-term

Maximum daily dose: 320 mg/day (immediate-release); 120 mg/day (modified-release)

Pediatric Dosing

Age Range: >18 years only

Dose: Use adult dosing

Max/day: 320 mg/day

Not recommended in children

Renal Dose Adjustment

CrCl / eGFR	Dose Adjustment
CrCl > 50 mL/min	No adjustment
CrCl < 50 mL/min	Use with caution; lower doses may be needed due to hypoglycemia risk

Calculate eGFR / CrCl →

Hepatic Adjustment

Caution in moderate-severe hepatic impairment.

Pregnancy & Lactation

Pregnancy: Category C

Avoid in pregnancy; use insulin.

Lactation: Unknown

Unknown; avoid if possible.

Top Drug Interactions

Interacting Drug	Effect	Severity
Other hypoglycemic agents	Additive hypoglycemia risk	Moderate
NSAIDs, Salicylates	Increased hypoglycemia risk	Moderate
Fluconazole, Miconazole	Increased hypoglycemia risk	Moderate

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Side Effects

Common

Hypoglycemia
Weight gain
GI upset
Dizziness
Headache

Serious / Discontinue If

Severe hypoglycemia
Hepatotoxicity (rare)
Hemolytic anemia (rare)
Agranulocytosis (very rare)

Contraindications

Type 1 diabetes
Diabetic ketoacidosis
Severe renal/hepatic impairment
Hypersensitivity to sulfonylureas

Available Indian Brands

Brand	Manufacturer	Price (approx)
Diamicron 80mg	Servier	10 tab â‚¹68
Glyclazide 80mg	Cipla	10 tab â‚¹45
Gliclazid MR 30mg	Intas	10 tab â‚¹70

Monitoring Required

Fasting and postprandial glucose
HbA1c every 3 months
Liver function baseline
Signs of hypoglycemia

Patient Counseling Points

Take with meals to reduce GI upset
Modified-release form provides more stable glucose control
Report hypoglycemia signs: shaking, sweating, confusion
Avoid skipping meals
Weight gain common; monitor dietary intake
Avoid alcohol

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Clinically reviewed by: Dr. Harini Sharma, MD (Endocrinology), Diabetes Pharmacology

Last reviewed: 2026-04-30

References

BNF â€” Gliclazide
ADA Sulfonylurea Class
Hypoglycemia Risk Profile

Disclaimer: This information is for clinical reference only. It is not exhaustive and does not substitute clinical judgement. Always verify current dosing against the manufacturer's prescribing information and current treatment guidelines. Drug prices are approximate and may vary.